Subject(s)
Female , Humans , Levamisole/pharmacology , Male , Nephrosis, Lipoid/immunology , Rosette Formation , T-Lymphocytes/drug effectsSubject(s)
Adolescent , Child , Child, Preschool , Drug Resistance , Female , Follow-Up Studies , Glomerular Mesangium/immunology , Glomerulonephritis/immunology , Glomerulosclerosis, Focal Segmental/immunology , Glucocorticoids/therapeutic use , Humans , Immunoglobulin M/analysis , Male , Nephrosis, Lipoid/immunology , RecurrenceSubject(s)
Adolescent , Adult , B-Lymphocytes/immunology , Child , Female , Humans , Male , Middle Aged , Nephrosis, Lipoid/immunology , Nephrotic Syndrome/immunology , T-Lymphocytes/immunologyABSTRACT
Serum immunoglobulin concentrations were determined in eighteen patients with minimal change nephrotic syndrome. Serum IgG and IgA were significantly decreased; whereas IgM was significantly increased in majority of the cases. Eight of the eighteen patients were treated with steroids. All the eight patients showed a significant increase in serum IgG and a decrease in IgM in response to steroid therapy. The increased serum IgM and decreased IgG before treatment and their restoration to normal levels after steroid therapy may suggest a possible defect in T-cell function.
Subject(s)
Adolescent , Adrenal Cortex Hormones/therapeutic use , Adult , Blood Proteins/analysis , Female , Humans , Immunoglobulins/analysis , Male , Nephrosis, Lipoid/immunology , Proteinuria/drug therapy , T-Lymphocytes/immunologyABSTRACT
Association of HLA antigens with certain diseases provide insights into genetically determined susceptibility to disease. Although nephrotic syndrome is one of the commonest diseases, it is poorly understood. A group of 57 patients suffering from a minimal lesion nephrotic syndrome (33 patients) and mesangioproliferative glomerulonephritis (24 patients) was studied for immunologic markers. The incidence of HLA-A w 24 is significantly greater in the minimal lesion nephrotic syndrome patients than in controls (18.7% in patients, 0% in controls, p < 0.01). This report fails to show a high incidence of specific HLA antigen in mesangioproliferative glomerulonephritis patients. We believe that the high incidence of HLA-Aw 24 in minimal lesion nephrotic syndrome is indicative of a congenital predisposition to nephrotic syndrome.